Assessing mortality and morbidity in people with psychotic disorders
An empirical framework for assessing mortality and morbidity in people with psychotic disorders: A 7-year prospective and 10-year retrospective follow-up of 2075 participants in the Survey of High Impact Psychosis (SHIP) using linked registers.
It is well established that physical morbidity and premature mortality are elevated in schizophrenia. The CIs/AIs who collaborated on the 2010 National Survey of High Impact Psychosis (SHIP), have cross-sectional data revealing rates of physical morbidity among SHIP participants well above population rates and exposing a very high cost burden. However there is a critical need for longitudinal data.
This NHMRC project grant funding study builds on a unique opportunity to use an innovative dual-methods strategy. 17 years (2000-2017) of mortality and physical morbidity outcome data from state and national administrative registers will be extracted. We will add these register data to previously-collected survey data for a large, nationally representative and comprehensively characterised sample of 2075 people aged 18-64 years with psychotic disorders who took part in SHIP.
The aims are to:
- Estimate rates of 7-year mortality and morbidity in people with a psychotic illness with separate estimates for:
- mortality due to natural versus unnatural causes
- potentially avoidable morbidity in order to establish much needed Australian benchmarks for assessing the impact of changes in public health policies.
- Examine the impact of sets of risk factors on 7-year mortality and morbidity in order to move beyond estimation of rates to understanding the aetiology of adverse physical health outcomes in psychotic disorders and informing clinical practice.
- Develop and validate predictive risk equations for cardiovascular disease (CVD) for use with people with psychotic disorders in order to address a clinical need for CVD predictive risk equations appropriate for use in this subpopulation.
- Calculate the economic burden of severe and acute physical morbidity in addition to mental health impacts in order to meet a service planning need for scarce and accurate data on costs of physical morbidity in psychotic disorders.
Prof Vera Morgan
- Prof John McGrath
- Prof Cherrie Galletly
- A/Prof Carol Harvey
- Prof David Castle
- Dr Martin Cohen
- Prof Assen Jablensky
- Prof Vaughan Carr
- Dr Amanda Neil
- Ms Anna Waterreus
- NHMRC Grant of $751,876 (2016-2020)